EVALUATION OF THE HEPATOPROTECTOR EFFECT OF A SUPPLEMENT WITH CURCUMA LONGA AGAINST REPERFUSION ISCHEMIA DAMAGE IN AN EXPERIMENTAL MODEL IN WISTAR RATS
نویسندگان
چکیده
Liver transplantation (LT) is the treatment for end-stage liver disease that may present graft rejection. Conditioning with natural products has shown great therapeutic utility, specifically against ischemia-reperfusion (IR). Curcumin protective activity, which why it proposed to evaluate whether curcumin (AGROVITAE-UANL) reduces IR damage. For thin layer chromatography, was started in 0.1% methanol using Si-60GF254 silica gel and chloroform: (95: 5). To verify presence of 3 curcuminoids, delay factors (Rf) equal standard (Sigma-Aldrich) were detected. 70% partial damage model, a midline laparotomy (L) performed, dissected, hepatic hilum clamped 1 hour subsequent sacrificed by exsanguination. 4 groups established: Sham (3% Tween 20; 500 µL x days; L); L + IR); SIGMA 200 mg / kg AGROVITAE+IR L+IR). ALT, AST, LDH, FA, BIL, PT, ALB, MDA Total Antioxidants (AOT) quantified UV-Vis. NF-kβ MPO evaluated RT-qPCR. The protocol approved ethics committee registration PI20-00002. Rf curcuminoids calculated: (0.80), Demethoxycurcumin (0.69) Bisdemethoxycurcumin (0.62). In significant increase AST LDH achieved hepatoprotective effect due decreases enzymes (Figure), there no change rest markers. No difference found oxidative stress markers AOT gene expression associated IR. Reyes et. al (2014) reported their Rf, agrees our results. Wang et al. (2017) decrease ALT values in treated consistent this study. Lintz model not be affected, contrasts results; however, groups, observed Zabala (2019) elevation what obtained Tinsay IR, on synthesis cholestasis markers, as study, can explained because produced cell lysis. Regarding non-difference MPO, other authors regulation inflammatory response genes would have an at longer reperfusion times (3, 6, 12 24h), models. confirmed AGROVITAE-UANL. effective increasing LDH. A AGROVITAE-UANL, decreasing AST. or cholestasis, so only There also MDA, established times, ruling out these pathways possible mechanisms action. declare conflict interest. Funded PAICYT-UANL-SA1458-20.
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ژورنال
عنوان ژورنال: Annals of Hepatology
سال: 2022
ISSN: ['2659-5982', '1665-2681']
DOI: https://doi.org/10.1016/j.aohep.2021.100633